Department of Systems Pharmacology and Translational Therapeutics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Research Study Abstract
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A Pilot Characterization of the Human Chronobiome
- Published on Dec 07, 2017
Abstract
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data from remote sensors, physiological and multi-omics analyses to assess the feasibility of detecting time dependent signals – the chronobiome – despite the “noise” attributable to the behavioral differences of free-living human volunteers. The majority (62%) of sensor readouts showed time-specific variability including the expected variation in blood pressure, heart rate, and cortisol. While variance in the multi-omics is dominated by inter-individual differences, temporal patterns are evident in the metabolome (5.4% in plasma, 5.6% in saliva) and in several genera of the oral microbiome. This demonstrates, despite a small sample size and limited sampling, the feasibility of characterizing at scale the human chronobiome “in the wild”. Such reference data at scale are a prerequisite to detect and mechanistically interpret discordant data derived from patients with temporal patterns of disease expression, to develop time-specific therapeutic strategies and to refine existing treatments.
Author(s)
- Carsten Skarke 1,2,5
- Nicholas F. Lahens 1,5
- Seth D. Rhoades 1
- Amy Campbell 1
- Kyle Bittinger 3,7
- Aubrey Bailey 3
- Christian Hofmann 3,8
- Randal S. Olson 4
- Lihong Chen 1
- Guangrui Yang 1
- Thomas S. Price 1
- Jason H. Moore 4,5
- Frederic D. Bushman 3,5
- Casey S. Greene 1,5
- Gregory R. Grant 5,6
- Aalim M. Weljie 1,5
- Garret A. FitzGerald 1,2,5
Institution(s)
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1
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2 Department of Medicine, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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3 Department of Microbiology, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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4 Institute for Biomedical Informatics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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5 Institute for Translational Medicine and Therapeutics (ITMAT), at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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6 Department of Genetics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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7 Division of Gastroenterology, Hepatology, and Nutrition, at Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
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8 Department of Food Science and Experimental Nutrition, Food Research Center (FoRC), School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Journal
Scientific Reports