Research Study Abstract

The role of moderate-to-vigorous physical activity in mediating the relationship between central adiposity and immunometabolic profile in postmenopausal women.

  • Published on Aug 2017

Objectives: To analyze the role of moderate-to-vigorous physical activity (MVPA) in mediating the relationship between central adiposity and immune and metabolic profile in postmenopausal women.

Materials and Methods: Cross-sectional study comprising 49 postmenopausal women (aged 59.26 ± 8.32 years) without regular physical exercise practice. Body composition was measured by dual-energy X-ray absorptiometry. Fasting blood samples were collected for assessment of nonesterified fatty acids, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), adiponectin, insulin and estimation of insulin resistance (HOMA-IR). Physical activity level was assessed with an accelerometer (Actigraph GTX3x) and reported as a percentage of time spent in sedentary behavior and MVPA. All analyses were performed using the software SPSS 17.0, with a significance level set at 5%.

Results: Sedentary women had a positive relationship between trunk fat and IL-6 (rho = 0.471; p = 0.020), and trunk fat and HOMA-IR (rho = 0.418; p = 0.042). Adiponectin and fat mass (%) were only positively correlated in physically active women (rho = 0.441; p = 0.027). Physically active women with normal trunk fat values presented a 14.7% lower chance of having increased HOMA-IR levels (β [95%CI] = 0.147 [0.027; 0.811]).

Conclusions: The practice of sufficient levels of MVPA was a protective factor against immunometabolic disorders in postmenopausal women.

Author(s)

  • Diniz TA 1,2
  • Rossi FE 2
  • Silveira LS 2
  • Neves LM 1
  • Fortaleza ACS 3
  • Christofaro DGD 4
  • Lira FS 2
  • Freitas-Junior IF 3

Institution(s)

  • 1

    Universidade de São Paulo (USP), São Paulo, SP, Brasil.
  • 2

    Grupo de Imunometabolismo e Exercício, Departamento de Educação Física, Universidade Estadual Paulista (Unesp), Presidente Prudente, SP, Brasil.
  • 3

    Centro de Estudos e Laboratório de Avaliação e Prescrição de Atividades Motoras (Celapam), Departamento de Educação Física, Unesp, Presidente Prudente, SP, Brasil.
  • 4

    Grupo de Estudos em Atividade Física e Saúde, Departamento de Educação Física, Unesp, Presidente Prudente, SP, Brasil.

Journal

Archives of Endocrinology and Metabolism

Categories

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